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Preparation
When living in Eso and/or running Incursions, you absolutely destroy your Faction standing with the Sanshas. You need to have atleast -2 standings with them to be able to use the good missions. Increasing the Faction Standing takes a extremely long time.
Luckily, there's a easy workaround. You get the full LP (The main income from missions) when being on a fleet with someone who is able to accept missions. That means you can still join fleets for missions and if you have an Alt with neutral standings with Sanshas, you can get him to accept all the missions for you and just run them with your main. It takes a bit longer to get to the standings required to accept L4 missions but you still get the whole payout, just split between 2 characters. Alternatively you can also just take all the rewards with your alt and that way you've got almost 100% of the efficiency you'd have if you ran the missions with your main.
The LP for the Sanshas are ~2900 ISK each when selling the High-Grade Nirvanas to Test, so it's a pretty good payout for the missions. As of 05.04.2020
The main Mission System is G-ME2K because it has 4 L4 Agents all in one station and its geography. so this is where you want to keep your ratting ships.
!unconfirmed!
[Caracal, L1/L2 Mission Caracal] Damage Control II Ballistic Control System II Ballistic Control System II Ballistic Control System II 1MN Monopropellant Enduring Afterburner Medium Shield Booster II Multispectrum Shield Hardener II Multispectrum Shield Hardener II Large Compact Pb-Acid Cap Battery Rapid Light Missile Launcher II Rapid Light Missile Launcher II Rapid Light Missile Launcher II Rapid Light Missile Launcher II Rapid Light Missile Launcher II Medium EM Shield Reinforcer I Medium Capacitor Control Circuit I Medium Warhead Calefaction Catalyst I Warrior II x2 Scourge Light Missile x7500 Inferno Light Missile x7500 Mjolnir Light Missile x7500 Nova Light Missile x7500
[Typhoon, L3/L4 Typhoon] Ballistic Control System II Ballistic Control System II Ballistic Control System II Missile Guidance Enhancer II Missile Guidance Enhancer II Nanofiber Internal Structure II Capacitor Power Relay II 500MN Microwarpdrive II Large Micro Jump Drive Missile Guidance Computer II Missile Guidance Computer II Sensor Booster II 'Arbalest' Cruise Launcher I 'Arbalest' Cruise Launcher I 'Arbalest' Cruise Launcher I 'Arbalest' Cruise Launcher I 'Arbalest' Cruise Launcher I 'Arbalest' Cruise Launcher I Drone Link Augmentor I Large Ionic Field Projector I Large Warhead Rigor Catalyst I Large Rocket Fuel Cache Partition I Warrior II x5 Berserker II x4 Caldari Navy Scourge Cruise Missile x3000 Caldari Navy Nova Cruise Missile x3000 Targeting Range Script x1 Caldari Navy Mjolnir Cruise Missile x3000 Missile Precision Script x2 Caldari Navy Inferno Cruise Missile x3000 Multispectrum Shield Hardener II x1
The above fit can be improved by adding T2 Cruise Launchers.
If going up against Caldari, fitting the Adaptive Invu Field instead of one Guidance Enhancer is recommended.
For a general guide search for the Mission here: https://wiki.eveuniversity.org/Mission_reports
When getting Missions from a L4 Agent, he sometimes gives you what's called a Burner Mission it will look something like this: https://prnt.sc/rt6fmv
If you are not specifically prepared you WILL DIE! , so as long as you don't intend to run these, you can safely decline them without any standing loss.
However, these Missions will give you the highest ISK/h possible. These have been extensively been researched and you can find a complete guide on them here: https://docs.google.com/document/d/1SAv6bnGM-5etLoPHxVtCsbsz8Q8feN5CFSEgUZclPLI/pub#h.ggnffko4mia0
Even with a large amount of enemies in the system, running Missions in Stain is suprisingly safe if you follow these rules: