Since Apocrypha the Gas Cloud Harvester I BPO and Gas Cloud Harvesting skill have been seeded on Empire markets. The skillbook is only seeded in a few stations and is 21.6 million ISK. Harvester I modules run around 1.5 million ISK. Additionally, the patch introduced Harvester IIs which can be invented and are currently priced around 2.5 million ISK each. For aspiring drug magnates, training Gas Cloud Harvesting V for the T2 harvesters is recommended as it's only a rank 1 skill. One Gas Cloud Harvester can be used for each trained level of Gas Cloud Harvesting. Named Gas Cloud Harvesters exist but are not worth the high cost.

Gas clouds can be found in Ladar sites in an associated COSMOS constellation. Additionally, COSMOS missions can be run to farm gas, but COSMOS agents can only be run once. There are eight 0.0 COSMOS constellations, each produces a gas required for one of the eight available combat boosters. Gas sites are most frequently found in the COSMOS constellations, but can spawn nearby within the same region. Additionally, all gas cloud sites require either Archaeology or Hacking to make use of them.

Cruiser/Battlecruiser hulls are best suited to this task. Whatever ship you use, some important factors are:

1. Must have 5 turret hardpoints. Seriously Gas Cloud Harvesting is a 1x skill, why not get it to V and not be fail?
2. Must have at least 350 CPU, because 5 Gas Cloud Harvester IIs take this much CPU.
3. As large of a cargo hold as you can muster. The cargo isn't because gas is large, but rather because it just makes it less annoying when you don't have to stop every 5 minutes to empty your hold.
4. A relatively fast (<5 second) align time is also desirable, in case you need to GTFO.

The Venture mining frigate is the only ship with a bonus to gas mining speed or quantity, however, though it would mean a reduced yield when compared to cruisers/battlecruisers as it has less turret slots. The only implant that affects gas mining is GH-80(1/3/5) implant series, which gives a 5% boost to harvesting speed (8 gas per minute).

It should be noted that gang boosted mining DOES improve gas mining speed. A perfect rorqual pilot, sieged, will increase you to 259m3/min.

In order to process the gas into a useful form, you will need a Standard Sooth Sayer Booster Reaction, which may be found reliably in certain Ladar Exploration Complexes. All sorts of standard reactions tend to sell for 1-3m on the Jita market, although there isn't much of a customer base.

You will also need a good quantity of gas as well as a POS to react it in. A single reaction can easily be done on a medium tower with some defenses, or you can shoehorn a pair of reactions on a Caldari Medium with few to no defenses (not recommended). Although the game states the reactors run at half speed on a medium, tests on Sisi show the reactions still run at full speed. The tower will require a Medium Biochemical Reactor Array, two General Storage Silos, a Hazardous Storage Silo, and a Biochemical Silo. 20 units of Azure Cytoserocin reacted with 100 units of water will produce 95 units of water and 15 units of Pure Standard Soothsayer Booster. This is not an actual dose of booster, but rather the main ingredient used to make them.

Beginning the final stage of production requires a Standard Sooth Sayer Booster Blueprint Copy. These blueprints are always 50-run, and require the Drug Manufacturing skill at level 1. Like the gas reaction, they are obtained from Ladar exploration complexes. There are no booster Blueprint Originals presently available in EVE.

With modest industrial skills, the ingredients for one run of the BPC are 5 Megacyte and 17 Pure Standard Sooth Sayer Booster. Each run of the BPC produces a single dose of Standard Sooth Sayer Booster.

Producing more potent types of Sooth Sayer is even more of a pain in the ass. You need an Improved Sooth Sayer Booster Reaction, which is much rarer than the standard variety. The ingredients are also more costly, requiring 100 units of Spirits, 15 units of Pure Standard Sooth Sayer Booster, and 15 units of Pure Standard X-Instinct Booster. This produces 95 units of spirits, and 12 units of Pure Improved Sooth Sayer. The X-Instinct ingredient is made in much the same way as the Sooth Sayer component, but with gas and a reaction acquired in Ladar exploration complexes located in the Northern Feythabolis COSMOS constellation, rather than Wicked Creek (Azure Cytoserocin).

Still with modest industrial skills, the ingredients for one run of the Improved Sooth Sayer Booster BPC are 5 Megacyte and 14 Pure Improved Sooth Sayer Booster. Each run of the BPC produces a single dose of Improved Sooth Sayer Booster.

The Strong version is made in much the same way as Improved boosters, requiring 100 Hydrochloric Acid, 15 Pure Standard Drop Booster, 12 Pure Improved Sooth Sayer Booster, and an extremely rare reaction. This produces 95 Hydrochloric Acid and 12 Pure Strong Sooth Sayer Booster. Due to the rarity of Strong Sooth Sayer BPCs, I do not know what a Strong Sooth Sayer Booster Blueprint requires per run. Even if it requires similar quantities of ingredients as Improved and Standard, it is still drastically more difficult to make these, the most precious class of Combat Boosters.

The Strong Sooth Sayer Booster Blueprint requires the following: Drug Manufacturing 5, 4 units of Megacyte and 11 units of Pure Strong Sooth Sayer Booster. Like the other blueprints, one unit of booster is produced.